Friday, March 16, 2012

Tradjenta and Metformin Sing a Duet

March 16th, 2012
written by Michael O’Leary
If you are taking metformin and Tradjenta to control your type 2 diabetes, Eli Lilly and Company has a new combination drug for you.

With a name that sounds more like a drug you’d buy at a cantina in Tijuana, Jentadueto was launched for U.S. sales with a Lilly press release Mar. 7. Developed in conjunction with its German partner Boehringer Ingelheim, Jentadueto combines the DPP-4 inhibitor in Lilly’s Tradjenta with metformin in a twice-daily pill. (Published site)


Jentadueto was approved by the FDA at the end of January as a prescription medicine to be used with exercise and diet to control blood sugar levels in adults with type 2 diabetes. It is not to be used for treatment of type 1 diabetes.


The drug comes in three dosage levels of the metformin component allowing doctors to adjust the metformin dose based on effectiveness and side effects, which can include lactic acidosis. This is a metabolism complication that can be serious and is caused by too much metformin. Other side effects include stuffy or runny nose and sore throat and diarrhea.

At this point, it is not known if it is safe to take Jentadueto with insulin, and you should not take if you have kidney, liver or heart problems.

At a monthly cost between $250 and $300, Lilly is working to get the drug on the preferred list of drugs for type 2 diabetes with insurance carriers, and the Boehringer Ingelheim Cares Foundation Patient Assistance Programs will make it available free-of-charge for patients without insurance coverage who meet certain household income level requirements. In the meantime some large pharmacy chains such as Walgreens, Rite-Aid and Walmart are offering discounts for people who have already signed up for their discount prescription cards.

Registration for the Jentadueto savings card is available online, and may reduce your cost substantially.

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